A physical model for PDZ-domain/peptide interactions
نویسندگان
چکیده
منابع مشابه
A physical model for PDZ-domain/peptide interactions
The PDZ domain is an interaction motif that recognizes and binds the C-terminal peptides of target proteins. PDZ domains are ubiquitous in nature and help assemble multiprotein complexes that control cellular organization and signaling cascades. We present an optimized energy function to predict the binding free energy (ΔΔG) of PDZ domain/peptide interactions computationally. Geometry-optimized...
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ژورنال
عنوان ژورنال: Journal of Molecular Modeling
سال: 2010
ISSN: 1610-2940,0948-5023
DOI: 10.1007/s00894-010-0725-5